CHIMERISM AND XENOTRANSPLANTATION
نویسندگان
چکیده
منابع مشابه
Chimerism and xenotransplantation. New concepts.
In both transplant and infectious circumstances, the immune response is governed by migration and localization of the antigen. If the antigenic epitopes of transgenic xenografts are sufficiently altered to avoid evoking the destructive force of innate immunity, the mechanisms of engraftment should be the same as those that permit the chimerism-dependent immunologic confrontation and resolution ...
متن کاملThe future of transplantation: with particular reference to chimerism and xenotransplantation.
The assumption for the last third of a century that stem cell-driven hematolymphopoietic chimerism was irrelevant to successful conventional whole organ transplantation has prompted alternative inadequate explanations of organ allograft acceptance. This assumption clouded the biologic meaning of successful organ as well as bone marrow transplantation, and precluded the development of a cardinal...
متن کاملXenotransplantation: Today and Tomorrow
Xenotransplantation using pig cells, tissues or organs is at present thought to be the best approach to alleviate the increasing shortage of human tissues and organs for the treatment of tissue and organ failure. This shortage is the reason that approximately 25% of the patients on a waiting list die before they could be treated with an appropriate donor organ. In the US, 30,974 organ transplan...
متن کاملPorcine Circoviruses and Xenotransplantation
Allotransplantation and xenotransplantation may be associated with the transmission of pathogens from the donor to the recipient. Whereas in the case of allotransplantation the transmitted microorganisms and their pathogenic effect are well characterized, the possible influence of porcine microorganisms on humans is mostly unknown. Porcine circoviruses (PCVs) are common in pig breeds and they b...
متن کاملClinical xenotransplantation.
Two baboon liver xenografts transplanted to patients with B virus hepatitis supported life for 70 and 26 days but did not function optimally despite minimum or no histopathologic findings of overt humoral or cellular rejection in serial biopsies. However, there was evidence of complement activation in both cases, which in retrospect was thought to explain the unsatisfactory outcome. Strategies ...
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ژورنال
عنوان ژورنال: Surgical Clinics of North America
سال: 1999
ISSN: 0039-6109
DOI: 10.1016/s0039-6109(05)70014-1